Symptoms

Of

 

Aflatoxin Mycotoxin

Exposure

 

With

Bibliography

 

(HOME) 

 

Compiled by

Deborah Cazden

July 9, 2001

 

 

Sources:

http://www.rand.org/publications/MR/MR1018.5/index.html

http://www.doh.wa.gov/ehp/oehas/mold.html

 

Please feel free to use this resource.

All I ask is to please keep my name on it, present it

as a whole document, and do not use it for profit.

Thank You.

 

 

2001 Deborah Cazden

All rights reserved

dcazden@gmail.com

 

 

Disclaimer,

This document is not meant to diagnose a health problem it is simply a tool. Please consult with your regular doctor if you have a health concern. No guarantee is implied by the use of this document. All information contained here is accurate to the best of my knowledge, but since the compilation is from other sources, I cannot guarantee all the information is correct.


Symptoms of aflatoxin exposure

 

 

 

 

 

 

 


N
A SYMPTOM (description)
M (references)
E


 

 

 

 

 

 

  1. Abdominal pain
    (Chao et al., 1991; Lye et al., 1995; Chao, 1992; Harrison and Garner, 1991)

 

 

 

 

 

 

  1. Alveolar injury (Injury to the air sacs in the lungs)
    (Coulombe et al., 1991; Coulombe, 1993; Jakab et al., 1994)

 

 

 

 

 

 

  1. Bile duct hyperplasia (pre-cancerous increase in the number of cells of the bile duct)
    (Bourgeois et al., 1971a)

 

 

 

 

 

 

  1. Bile duct metaplasia (change in the cell structure of the cells in the bile duct)
    (Chao et al., 1991)

 

 

 

 

 

 

  1. Brain injury
    (Schafer and Sorrel, 1997)

 

 

 

 

 

 

  1. Cancer
    (Steyn, 1995; Coulombe et al., 1991, McLean and Dutton, 1995; Tutelyan and Kravchenko, 1981)

 

 

 

 

 

 

  1. Carbohydrate metabolism impaired
    (McLean and Dutton, 1995; Tutelyan and Kravchenko, 1981; Verma and Choudhary, 1995)

 

 

 

 

 

 

  1. Catecholamine levels decrease (such as epinephrine, adrenaline, norepinephrine, and dopamine)
    (Kimbrough, Llewellyn, and Weekley, 1992)

 

 

 

 

 

 

  1. Centrilobular coagulative necrosis (cell death in the central region of the kidney)
    (Chao et al., 1991)

 

 

 

 

 

 

  1. Cerebral edema (swelling of the brain)
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Coma
    (Chao et al., 1991; Chao, 1992; Bourgeois et al., 1971a; Northup et al., 1995; Jakab et al., 1994; Smith and Moss, 1985)

 

 

 

 

 

 

  1. Convulsions
    (Chao et al., 1991; Chao, 1992; Smith and Moss, 1985)

 

 

 

 

 

 

  1. Corrhachia (as related to Reyes syndrome)
    (Reye et al. 1951, 1962)

 

 

 

 

 

 

  1. Cough
    (Bourgeois et al., 1971a)

 

 

 

 

 

 

  1. Dark Urine

 

 

 

 

 

 

  1. Death
    (Chao et al., 1991; Chao, 1992; Northup et al., 1995; Jakab et al., 1994; Bourgeois, 1971a, 1971b)

 

 

 

 

 

 

 


N
A SYMPTOM (description)
M (references)
E


 

 

 

 

 

 

  1. Diarrhea
    (Bourgeois et al., 1971a; Chao et al., 1991; Lye et al., 1995; Chao, 1992; Harrison and Garner, 1991)

 

 

 

 

 

 

  1. Fatty degeneration of heart muscle (especially atrial and conduction systems)
    (Bourgeois, Olson, et al., 1971)

 

 

 

 

 

 

  1. Fatty degeneration of the liver
    (Bourgeois et al., 1971a)

 

 

 

 

 

 

  1. Fatty infiltrations heart
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Fatty infiltrations kidney
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Fatty infiltrations of liver
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Fever
    (Chao et al., 1991; Lye et al., 1995; Chao, 1992; Harrison and Garner, 1991; Smith and Moss, 1985)

 

 

 

 

 

 

  1. Hematemesis (throwing up blood)
    (Chao et al., 1991; Lye et al., 1995; Chao, 1992; Harrison and Garner, 1991)

 

 

 

 

 

 

  1. Hepatic glycogen stores are depleted (reduced amounts of glycogen in the liver)
    (McLean and Dutton, 1995; Tutelyan and Kravchenko, 1981; Verma and Choudhary, 1995)

 

 

 

 

 

 

  1. Hepatocellular carcinoma (liver cancer)
    (Nigam et al., 1994, Groopman et al., 1996)

 

 

 

 

 

 

  1. High blood sugar
    (McLean and Dutton, 1995; Tutelyan and Kravchenko, 1981; Verma and Choudhary, 1995)

 

 

 

 

 

 

  1. Hypoglycemia (as related to Reyes syndrome)
    (Reye et al. 1951, 1962)

 

 

 

 

 

 

  1. Immunosuppression
    (Griffiths et al., 1996; Jakab et al., 1994; Raisuddin et al., 1993; Cysewski et al., 1978; Dimitri and Gabal, 1996)

 

 

 

 

 

 

  1. Impaired child development
    (Groopman et al., 1996)

 

 

 

 

 

 

  1. Impaired child health
    (Groopman et al., 1996)

 

 

 

 

 

 

  1. Impaired nutritional intake
    (Guengerich et al., 1996)

 

 

 

 

 

 

 


N
A SYMPTOM (description)
M (references)
E


 

 

 

 

 

 

  1. Impairs cell-mediated immunity
    (Griffiths et al., 1996; Raisuddin et al., 1993; Cysewski et al., 1978; Dimitri and Gabal, 1996)

 

 

 

 

 

 

  1. Impairs humoral immunity
    (Griffiths et al., 1996; Raisuddin et al., 1993; Cysewski et al., 1978; Dimitri and Gabal, 1996)

 

 

 

 

 

 

  1. Increased infections
    (Groopman et al., 1996)

 

 

 

 

 

 

  1. Jaundice

 

 

 

 

 

 

  1. Lipid metabolism impaired
    (McLean and Dutton, 1995; Tutelyan and Kravchenko, 1981; Verma and Choudhary, 1995)

 

 

 

 

 

 

  1. Liver cancer
    (Massey, 1996; Autrup et al., 1993; Coulombe, 1993)

 

 

 

 

 

 

  1. Liver encephalopathy (damage to the brain and nervous system as a complication of liver disorders)
    (Bourgeois et al., 1971a)

 

 

 

 

 

 

  1. Liver failure
    (Chao et al., 1991; Northup et al., 1995; Jakab et al.,1994; Bourgeois, 1971a, 1971b; Lye et al., 1995; Chao, 1992; Harrison and Garner, 1991)

 

 

 

 

 

 

  1. Liver failure and associated disorders (e.g., Reyes syndrome)
    (Schafer and Sorrel, 1997)

 

 

 

 

 

 

  1. Liver injury
    (Fernandez, Ramos, et al., 1995; Fernandez, Verde, et al., 1995)

 

 

 

 

 

 

  1. Low blood sugar
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Lung cancer
    (Massey, 1996; Autrup et al., 1993; Coulombe, 1993)

 

 

 

 

 

 

  1. Lysis of lymphatic tissues (rupture of the cells in the blood stream)
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Macrovesicular steatosis (fatty degeneration of ________________)
    (Chao et al., 1991)

 

 

 

 

 

 

  1. Mitogenic (causes cells to divide)
    (Griffiths, Rea, et al., 1996).

 

 

 

 

 

 

  1. Nausea
    (Chao et al., 1991; Northup et al., 1995; Jakab et al., 1994; Bourgeois, 1971a, 1971b)

 

 

 

 

 

 

  1. Neuronolysis (rupture of nerve cells)
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

 


N
A SYMPTOM (description)
M (references)
E


 

 

 

 

 

 

  1. Prolonged prothrombin times
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Pulmonary hemorrhage (bleeding in the lungs)
    (Coulombe et al., 1991; Coulombe, 1993; Jakab et al., 1994)

 

 

 

 

 

 

  1. Renal failure (kidney failure)
    (Chao et al., 1991; Lye et al., 1995; Chao, 1992; Harrison and Garner, 1991)

 

 

 

 

 

 

  1. Reoccurring infections
    (Jakab et al., 1994; Raisuddin et al., 1993)

 

 

 

 

 

 

  1. Reproductive problems
    (Coulombe, 1993; Aulerich et al., 1993; Bonomi et al., 1995)

 

 

 

 

 

 

  1. Respiratory distress (difficulty breathing)
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Respiratory failure
    (Chao et al., 1991; Lye et al., 1995; Chao, 1992; Harrison and Garner, 1991)

 

 

 

 

 

 

  1. Respiratory injury
    (Chao et al., 1991; Northup et al., 1995; Jakab et al., 1994; Bourgeois, 1971a, 1971b)

 

 

 

 

 

 

  1. Seizures
    (Chao et al., 1991; Chao, 1992; Northup et al., 1995; Jakab et al., 1994; Bourgeois, 1971a, 1971b; Lye et al., 1995; Harrison and Garner, 1991)

 

 

 

 

 

 

  1. Seratonin levels decrease
    (Kimbrough, Llewellyn, and Weekley, 1992)

 

 

 

 

 

 

  1. Serum transaminases elevated (elevated transaminases in the blood)
    (Chao et al., 1991; Chao, 1992)

 

 

 

 

 

 

  1. Teratogen (causes birth defects)
    (Raisuddin et al., 1993)

 

 

 

 

 

 

  1. Tracheal epithelial damage (damage to the lining of the trachea)
    (Coulombe et al., 1991; Coulombe, 1993; Jakab et al., 1994)

 

 

 

 

 

 

  1. Tremorgenic (causes tremors)
    (Land et al. 1984)

 

 

 

 

 

 

  1. Vomiting
    (Chao et al. 1991; Chao, 1992; Northup et al., 1995; Jakab et al., 1994; Bourgeois, 1971a, 1971b; Smith and Moss, 1985)